More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
High Prevalence of Undocumented SARS-CoV-2 Infections in the Pediatric Population of the Tyrolean District of SchwazArticle Published on 2022-10-192022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 진단, [키워드] Adding age anti-nucleocapsid antibody Anti-spike anti-spike antibody binding children collected confirmed cases District durable immune response household contacts humoral Humoral response immune Infection Neutralizing neutralizing antibody participated PCR-confirmed pediatric pediatric infection plasma sample Population Prevalence proportion provided questionnaire reported SARS-CoV-2 SARS-COV-2 infection Seroprevalence silent study participant Symptom translated Transmission unreported infection. vaccination [DOI] 10.3390/v14102294 PMC 바로가기
The impact of COVID-19 on implementation of mass testing, treatment and tracking of malaria in rural communities in Ghana: A qualitative studyArticle Published on 2022-10-132022-11-15 Journal: PLoS ONE [Category] 진단, [키워드] addition affected analysed Analysis children Community Complication conducted Coverage COVID-19 COVID-19 pandemic Effect eight English finding group Health health worker identify implementation increase in Intervention introduced malaria mass methodology observation pandemic parent participant public health respond responsible Transcription translated treat Treatment Volunteer volunteers was used were recorded [DOI] 10.1371/journal.pone.0275976 PMC 바로가기
Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main ProteaseArticle Published on 2022-10-132022-11-15 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL pro administration antiviral activity Antiviral treatment binding cell types complexes COVID-19 COVID-19 pandemic crystal structure enzyme inactive inhibitor M pro polyprotein potent protease Resolution SARS-CoV-2 translated viral replication Viral RNA yield [DOI] 10.1021/acs.jmedchem.2c01131 PMC 바로가기
ORF8 protein of SARS-CoV-2 reduces male fertility in miceSARS-CoV-2의 ORF8 단백질은 쥐의 수컷 생식력을 감소시킵니다Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] abnormality accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered Analysis Antibody titer Antibody titers Betacoronavirus body weight can be used circulating Col1a1 convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cultured cells decreased expression dependent on Endoplasmic reticulum examined Food Intake Gene Expression genus genus Betacoronavirus Human in vivo indicated Infection infertility inhibited inhibitor injection male mice Morphological N-terminal observation Open reading frame open reading frames ORF8 ORF8 protein oxygen peptide peptide sequence plasma sample plasma samples Protein provide reactive oxygen specy reduce reproductive reproductive system respiratory SARS-CoV-2 secretion secretion. sequence severe acute respiratory syndrome Coronavirus signal peptide testes the patient translated vitality [DOI] 10.1002/jmv.27855 PMC 바로가기 [Article Type] Article
Precision oncology for intrahepatic cholangiocarcinoma in clinical practice Research Published on 2022-08-192022-10-05 Journal: British Journal of Cancer [Category] 변종, 유전자 메커니즘, 임상, [키워드] alteration applied approach ARID1A ATM BAP1 BRAF Care CDKN2A CDKN2B Chemotherapy Chemotherapy treatment Cholangiocarcinoma Clinical practice Clinical treatment Combination Deterioration DNA and RNA FGFR2 FGFR3 formalin-fixed paraffin-embedded gene fusion IDH1 IDH2 intrahepatic involved loci molecular NRG1 oncology Patient patients performance status PIK3CA poor prognosis Probability progression receiving Result Sequencing significantly higher SMARCA4 survival target targeted therapy therapy tissue TP53 translated Treatment was performed [DOI] 10.1038/s41416-022-01932-1 [Article Type] Research
Gene Network Analysis of the Transcriptome Impact of SARS-CoV-2 Interacting MicroRNAs in COVID-19 DiseaseCOVID-19 질병에서 SARS-CoV-2 상호작용 MicroRNA의 전사체 영향에 대한 유전자 네트워크 분석Review Published on 2022-08-172022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] affected Analysis biochemical biological processes Cell cell cycle cell surface receptor changes characterized COVID-19 COVID-19 disease cytokine death DEGs differentially expressed differentially expressed gene Differentially expressed genes downregulated exploratory FIVE functional enrichment Functional enrichment analysis Gene Expression gene network Health Organization heart Impact involved kidneys list lung Lymph node microRNA MicroRNAs mitochondrial mitotic mitotic cell modulation molecular Multiorgan multiorgan disease network network analysis network analysis. pathological mechanism Pathways Perspective predicted provide reported SARS-CoV-2 SARS-CoV-2 virus signaling pathway submitted surface receptor target tissue tissues transcriptomes translated upregulated WHO with COVID-19 World Health Organization [DOI] 10.3390/ijms23169239 PMC 바로가기 [Article Type] Review
Proceedings of the ISCT scientific signature series symposium, “Advances in cell and gene therapies for lung diseases and critical illnesses”: International Society for Cell & Gene Therapy, Burlington VT, US, July 16, 2021Review article Published on 2022-08-012022-10-05 Journal: Cytotherapy [Category] 비임상, [키워드] biennial bioengineering Biology Cell Cell therapy cell-based therapies Critical Critical illness European Evolution Gene therapy illness illnesses independent ISCT Lung disease Lung injury mechanism Mesenchymal stromal cell mitigate MSCs Patient preclinical data Proceeding pulmonary reflect respiratory Respiratory disease Sery signature Society state stromal cell symposium therapy thought took place transfer translated University of Vermont vectors [DOI] 10.1016/j.jcyt.2021.11.007 [Article Type] Review article
BioAutoML: automated feature engineering and metalearning to predict noncoding RNAs in bacteriaBioAutoML: 박테리아의 비코딩 RNA를 예측하기 위한 자동화된 기능 엔지니어링 및 금속 학습Article Published on 2022-07-182022-09-11 Journal: Briefings in Bioinformatics [Category] Coronavirus, 유전자 메커니즘, [키워드] accelerate Algorithm Algorithms Analysis approach automated automatically Bacteria benefit bioinformatics Care category components coronavirus disease Coronavirus disease 2019 coronavirus vaccine CRISPR develop Diseases domain Drug discovery Economy eight evaluate experimental results extraction feature Feature selection Features Health Health care helping housekeeping information knowledge machine learning mechanism ncRNA ncRNAs noncoding RNA Noncoding RNAs Precision predict Predictive Quantitative recent RECIPE reducing Regulatory selected sequence time-consuming translated tuning [DOI] 10.1093/bib/bbac218 PMC 바로가기 [Article Type] Article
Saquinavir: From HIV to COVID-19 and Cancer Treatment사퀴나비르: HIV에서 COVID-19 및 암 치료까지Review Published on 2022-07-052022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] 3CLpro anticancer antivirals Apoptosis approval approved drug Cancer Cancer cells cancer treatment Cell changed clinical trial clinical trials Combination COVID-19 COVID-19 outbreak cytotoxicity disease drug Drug repurposing Effect Follow-up help HIV impede in silico in vitro in vivo increased survival Invasion lack mind Neuroblastoma pathway pharmacological promise protease Protease inhibitor Research saquinavir saquinavir. SARS-CoV-2 main protease shown tested the SARS-CoV-2 therapy translated Treatment virus [DOI] 10.3390/biom12070944 PMC 바로가기 [Article Type] Review